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Non dihydropyridine CCB (as well as class IV antiarrythmic). Indicated for HTN, angina and AV node arrythmias (such as SVT). The drugs in this class are negative inotropes and can worsen CHF.

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Amlodipine is one of the least likely DHPs to cause reflex tachycardia and therefore can be used in CHF as well as to control HTN and angina. Starting dosages are typically 2.5-5mg/day with a maximum dose of 10mg QD. Do you wish you could review the top 250 drugs from beginning to end?

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However, it is unstable in both acidic and basic conditions, and thus did not find clinical application. It is effective only against Gram positive bacteria, is acid labile and can be destroyed by ß-lactamases. It is used as its sodium or potassium salt in parentral preparations, or as long acting IM injections as the procaine salt or benzathine salt. Drug of choice if hypertension must be controlled during pregnancy (Pregnancy category B). Common side effects include; sedation, lethargy, depression and postural hypotension but there is a possibility of hemolytic anemia or hepatitis. Control of hypertension during pregnancy is vital to preventing fetal complications as well as preeclampsia.

1. When used in combination with potassium sparing diuretics or ACE-I hyperkalemia can occur.
2. It is indicated in the same instances as Dobutamine, but is cleared both renally and through hepatic mechanisms in approximately 2 hours.
3. FDA indicated for angina, arrythmias and hypertension.
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Gemfibrozil increases the active form of the statin in the body, leading to a higher incidence of rhabdomyolosis. Indicated in life threatening ventricular tachycardia (though it works well for controlling premature ventricular contractions (PVCs) in people without arrythmias). It is extremely proarrythmic due to its negative inotropic effects (which depress myocardial function).

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Tolerance does not develop to the cough and if it greatly bothers the patient switching to an ARB many be indicated. ACE-I are one of the only antihypertensive drugs that will actually improve quality of life, resulting in the patient «feeling better». Care must be taken if these drugs are used in combination with potassium sparing diuretics or ARBs due to increased propensity of hyperkalemia. Indicated in SVT and ventricular tachycardia (V-tach). Procainamide is pharmacokinetically dosed with a therapeutic range between 4-12mcg/ml. 50% of the drug is cleared renally and 50% is cleared hepatically to the active metabolite NAPA, which is actually its own antiarrythmic drug that can be grouped in class III.

This may or may not be unique to this drug. An HMG CoA reductase inhibitor («statin») of moderate potency, lowering LDLc by approximately 35%. It is metabolized renally, and therefore is not subject to as many drug interactions as Atorvastatin. https://sober-house.net/alprazolam-oral-route-side-effects/ Fluvastatin is the least potent of the statins, lowering LDLc by less than 30%. Like most of the other statins, it is metabolized via CYP 450 system in the liver. However, Fluvastatin is an inhibitor of 2C9 and not a substrate of 3A4.

Due to the inactivation of protein C and S, warfarin therapy must be initiated concomitantly with heparin, to combat the initial hypercoaguable state. Warfarin therapy is monitored via the patients INR. The drug is notorious for drug interactions due to its narrow therapeutic window. Other drugs that are CYP2C9 inducers or inhibitors interact with warfarin, as well as foods that contain vitamin K (such as green, leafy vegetables). Patients should be instructed to watch for bleeding/bruising while on warfarin, especially on the torso. The class is contraindicated in decompensated HF, but prevents destructive remodeling if given in stable HF and is the drug of choice for HTN complicated by HF.

It is indicated in the same instances as Dobutamine, but is cleared both renally and through hepatic mechanisms in approximately 2 hours. It has been shown to be less proarrythmic than Dobutamine, but much more costly. Milrinone is the drug of choice if a patient has previously been on β-blocker therapy, due to the fact that Dobutamine is a β-agonist and may not be 100% effective in these patients. Indicated as second line therapy for Ventricular Tachycardia (V-tach). It is pharmacokinetically dosed with a therapeutic range between 2-6 mcg/ml.

Like Atorvastatin, it is used to lower LDLc. It is the 3rd most potent statin, lowering LDL by approximently 50%. ambien Like Atorvastatin, it also is metabolized via CYP 3A4 and is subject to the applicable drug interactions.

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